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There is an increased risk of thromboembolic events occurring when cytotoxic agents are used tamoxifen in combination with NOLVADEX .
Tamoxifen reduced letrozole plasma tamoxifen concentrations by 37% .
The effect tamoxifen of tamoxifen on metabolism and excretion of other antineoplastic drugs, such as cyclophosphamide and other drugs that require mixed function oxidases for activation, is not known .

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